The combined treatment ofTACE and HAIC with molecular targeted drugs and ICIs has shown efficacy in the management of unresectable hepatocellular carcinoma (HCC) and may offer significant survival benefits. However, not all patients benefit equally from this quadruple therapy [TACE-HAIC combined with molecular targeted drugs and ICIs], which underscores the need to establish a predictive model for assessing the prognosis of unresectable HCC patients following this treatment regimeMethods.